Oligonucleotides

Custom oligos in bulk at a high purity level

At OEM by QIAGEN, we know that high-quality, pure oligonucleotides can make a difference. We manufacture premium quality custom oligos in big batches for molecular and in-vitro diagnostic applications, using AIE-HPLC and RP-HPLC methods, resulting in a very high purity level. Critical raw materials are tested and approved before use in bulk production for lot-to-lot reproducibility. Synthesis processes are optimized and automated to meet stringent requirements, including a no-contamination guarantee for IVD-grade. Moreover, we work according to cGMP/QSR guidelines in ISO-certified facilities, providing full traceability with extensive Production Batch Records.

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Oligonucleotides types and quality levels

	Fast track	Development-LC	Development-HPLC	IVD
Traceability	None	Partial	Partial	Full
Purification	LC/HPLC	LC	HPLC	HPLC
HPLC column	Non dedicated	N/A	Non dedicated	Dedicated
Clean room	None	Optional	Optional	Dedicated
Quality systems	ISO 9001	ISO 9001 ISO 13485	ISO 9001 ISO 13485	ISO 9001 ISO 13485 21 CFR Part 820
QC control	Optional QC	Optional QC	Customized QC	In process/ Final
Product release	Final QC	Technical release	Technical release	QA release
Documents provided	Compilation of results	Simplified CoA	Simplified CoA	Full CoA
Critical raw material control	Partial	Partial	Partial	Full
Environmental control	Yes	Yes	Yes	Yes
Manufacturing documents	None	Simplified production batch record	Simplified production batch record	Production batch record
Synthesis scale	0.04–0.1 μmol	0.15–60 μmol	1–60 μmol	1–60 μmol

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* Analytical methods for troubleshooting or evaluation of third-party products.

Compliant, certified facilities

ISO and GMP certified manufacturing facilities in multiple sites worldwide provide you with access to our broad range of custom oligos and other OEM products. At OEM by QIAGEN, we pride ourselves on excellent quality control processes, global reach and long-term customer support. We help assay developers consolidate the supply chain to get bulk components exactly where and when needed.

Custom LNA oligos

Designing Locked Nucleic Acid (LNA) oligonucleotides is complex and requires expertise. We can support you with off-the-shelf or custom LNA oligos manufactured in big batches.

From our oligonucleotides portfolio

Oligonucleotide categories	Unmodified oligonucleotides	Modified oligonucleotides
• Primers • Probes • SCORPIONS • Locked Nucleic Acid (LNA) • NGS Adapters • Molecular Beacons	• Unmodified oligonucleotides up to 170 bases • Homopolymers such as polyA and polyT	• Fluorescent groups • Fluorescent groups combined with Quenchers • LNA^® containing oligonucleotides • MGB-Eclipse® Dark Quencher • EBQ • Superbases • SuperA^®, SuperG^® and SuperT^® • Biotin • Phosphate • Spacers • Amino … and more

Oligo modifications

Take a look at further modification capabilities of OEM oligonucleotides in bulk.

Bulk Oligos

Custom oligos in bulk at a high purity level

Oligonucleotides types and quality levels

Compliant, certified facilities

Custom LNA oligos

From our oligonucleotides portfolio

Learn about diverse OEM solutions