QIAcube Connect – RNA/DNA Extraction Instrument

For fully automated, spin-column-based nucleic acid extraction that you can manage from outside the lab using QIAsphere

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QIAcube Connect

Cat no. / ID.   9002864

Instrument, 1-year warranty on parts and labor
Product
QIAcube Connect
QIAcube Connect System PRV-1
QIAcube Connect System FUL-2
QIAcube Connect System FUL-3
QIAcube Connect is designed to perform fully automated purification of nucleic acids and proteins in molecular biology applications. The system is intended for use by professional users trained in molecular biological techniques and the operation of QIAcube Connect.
Virtual Demo
Explore the virtual tour to learn more and see this product in action.

Features

  • Automates over 80 QIAGEN kits with over 140 standard protocols for DNA, RNA and protein sample processing
  • Optional protocol customization expands the use to over 3000 protocols
  • Get reproducible results with less hands-on time
  • Monitor runs remotely, for quick response times, through the QIAsphere App

Product Details

QIAcube Connect lets you automate your manual spin-column-based sample preparation kits right out of the box and purify up to 12 samples in a single run.

To work even faster, get kits specifically designed for use with QIAcube Connect. These come with spin columns and tubes already loaded onto the rotor, so you don't have to put them in yourself:

QIAcube Connect operates in conjunction with QIAcube Connect Accessories.

For QIAcube resources, visit the QIAcube (classic) resource page.

Performance

The plug-and-play QIAcube Connect simplifies purification by automating QIAGEN spin-column kits. No change of chemistry is needed, so startup is fast, results are immediate, and performance is comparable to the manual procedure.

Principle

QIAcube Connect includes a centrifuge, heated shaker, pipetting system and robotic gripper (see " The QIAcube Connect worktable"). These let the QIAcube Connect fully automate more than 80 QIAGEN spin column kits.

UV light decontamination

QIAcube Connect decontaminates your full worktable with built-in UV light (see " The QIAcube Connect UV light") to prevent carryover between samples (see " Genomic DNA (gDNA) barely detectable after UV light exposure").

Remote connectivity with QIAsphere

QIAcube Connect is QIAsphere-ready. QIAsphere gives full connectivity so you can step out of the lab to ponder on your research while keeping an eye on your instrument run status.

Stay alert to important instrument events with QIAsphere's push notifications. You can even check maintenance status and manage run reports from anywhere, at anytime. Increase the efficiency and productivity of your lab. Learn more about QIAsphere.

Barcode scanner

Track samples and sample prep kit information throughout the process, using the handheld barcode scanner that comes with the kit.

Illuminated worktable

Light inside the instrument makes it easier for you to load your samples and perform your experiments.

Protocols for various sample types

QIAcube Connect has a variety of pre-installed protocols for purification of RNA, genomic DNA, plasmid DNA, viral nucleic acids and proteins, plus DNA and RNA cleanup. All standard protocols in the expanding range can also be downloaded free of charge. Customized protocols can also be requested.

See figures

Procedure

QIAcube Connect isolates highly pure nucleic acids or proteins using a spin-column-based lyse, bind, wash and elute procedure (see '' Automated QIAprep Mini Standard procedure'').

Unparalleled ease-of-use

A large touchscreen (see figure '' The QIAcube Connect touchscreen'') simplifies protocol selection. Clear on-screen messages guide you through worktable setup. You are unlikely to make mistakes because the labware and accessories fit onto the worktable only in the correct orientation. In addition, a fully automated load check helps to ensure that samples, reagents and labware are loaded correctly.

Dedicated kits for DNA and RNA preps

Dedicated QIAcube Connect kits further simplify automated spin-preps for purification of RNA, genomic DNA and viral RNA. Rotor-adapters that come with the kits are pre-loaded with spin columns and elution tubes, so they are ready to use right out of the box. And then, to lessen the risk of errors even more, tubes required for the manual procedure are not included in kits dedicated for use with QIAcube Connect.

See figures

Applications

QIAcube Connect is highly suitable for academic research laboratories as well as pharmaceutical, biotechnology, and biomedical research laboratories performing applications, such as:

 

Services

Have your throughput demands increased? Do you want to expand your application range or further streamline workflows? Do you need to manage more complex samples? Do you need improved connectivity?

If the answer to any of these questions is yes, then QIAGEN’s trade-in/trade-up program is just right for you!

QIAGEN makes it easy to keep up to speed with the latest automation and sample processing technologies. Simply exchange an old instrument for a new one. Improve your efficiency by trading in a competitor instrument or trading up with an older QIAGEN instrument.

Learn more about trade-in/trade-up opportunities.

Supporting data and figures

Specifications

FeaturesSpecifications
technicaldataPower: 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1000 VA.; Fuse: 2x T6.3A L 250V; Overvoltage category: II
operatingtemperature18 to 28ºC (64.4 to 82.4ºF)
relativehumidity15–75% (non-condensing)
placeofoperationFor indoor use only
pollutionlevel2
environmentalclass3K2 (IEC 60721-3-3)
storageconditionsTemperature: 15ºC to 30ºC (59ºF to 86ºF) in manufacturer’s package; Relative humidity: Max. 75% (non-condensing); Environmental class: 1K2 (IEC 60721-3-1)
instrumentdimensionsDimensions (hood closed): width 65 cm (25.6 in.), height 58 cm (22.8 in.), depth 62 cm (24.4 in.); Dimensions (hood open): width 65 cm (25.6 in.), height 86 cm (34 in.), depth 62 cm (24.4 in.); Mass: QIAcube Connect: 71.5 kg (157.6 lb.), Accessories: 3 kg (6.6 lb.)
centrifuge10,640 rpm maximum, 12,000 x g maximum, swing-out rotor maximum 45°, 12 rotor positions
shakerSpeed 100–2000 rpm, amplitude 2 mm, heating range of ambient temperature to 70°C (158°F), ramp-up time of <5 minutes from ambient temperature to 55°C (±3°C). Difference in the temperature detected by the internal sensor and the temperature of the sample liquid is approximately –2°C.
pipettingsystemSyringe size 1 ml, pipetting range 5–900 µl
tablecapacityUp to 12 samples per run
touchscreen10.4” TFT Touchscreen, active area 211.2 x 158.4 mm, resolution 800*600 SVGA
dataoutputUSB stick: USB2.0; Compatible OS: Windows 8, Windows 7, Windows Vista, Windows XP (SP3 or later); Mac OS x 10,1 or later; Operating temperature range: 0ºC to 35ºC; Operating humidity range: 10 to 90% (with no condensation); Storage temperature range: –20ºC to 60ºC (–4ºF to 140ºF); Storage humidity range: 10 to 90% (with no condensation); Formatting: FAT32
uvlampWavelength: 278nm; Optical power: 200-300mW
specialfeatureHandheld scanner; Scan pattern: Area Image (838 x 640-pixel array); Motion tolerance: Up to 610 cm/s (240 in/s) for 13 mil UPC at optimal focus; Symbol contrast: 20% minimum reflectance difference; Decode capability: Reads standard 1D, PDF, 2D, Postal and OCR symbology
softwareQIAGEN protocols are pre-installed on the QIAcube Connect.
altitudeUp to 2000 m (6500 ft)
transportationconditions–25°C to 60°C (–13°F to 140°F) in manufacturer's package; Max. 75% relative humidity (non-condensing); Environmenal class: 2K2 (IEC 60721-3-2)

Service Plans

QIAcube Connect, Premium Agreement

Cat. No. / ID. / ID.   9245209

On-site QIAcube Connect instrument repair, including travel, labor and parts, for a period of 1 year. Response time of next business day. Includes 1 Preventive Maintenance or Inspection Service during the Premium Agreement period.
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Available on demand

QIAcube Connect, Core Agreement

Cat. No. / ID. / ID.   9245260

For the QIAcube Connect, one on-site repair service and one on-site Preventive Maintenance or Inspection Service, including travel, labor and spare parts for a period of one year. Response time of five business days. Includes a 10% discount on additional repair service during the Core Agreement period.
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Available on demand

QIAcube Connect, Preventive Subscription

Cat. No. / ID. / ID.   9245210

One on-site Preventive Maintenance or Inspection Service visit for the QIAcube Connect, including travel, labor and parts. Includes a 10% discount on repair services during the Preventive Subscription period.
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Available on demand

QIAcube Connect, Full Agreement

Cat. No. / ID. / ID.   9245208

On-site QIAcube Connect instrument repair, including travel, labor and parts, for a period of one year. Response time of two business days.
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Available on demand

Resources

Instrument User Manuals (4)
User-Developed Protocols (1)
This protocol has been adapted to allow the user to replace the epithelial transfer and sperm pellet wash steps with an automated protocol using the QIAcube Connect.
Validation Reports (1)
Instrument Technical Documents (1)
The QIAcube Connect System and 21 CFR Part 11 Regulations
Brochures & Guides en (1)
A versatile workflow for the detection of low-abundance microbes
Certificates of Analysis (1)